Serum Neurofilament Light Chain: A Potential Biomarker for Peripheral Neuropathy

In some neurological diseases, advanced examinations can be used as diagnostic tools. Several indicators have also been discovered that to assess the severity of neuronal damage and disease progression. Neurofilament light chain (NfL) is a cytoskeleton protein makes up structure neuron axons released when injured, allowing it injury severity. NfL was first diagnose central nervous system disorders like dementia, multiple sclerosis, other neurodegenerative diseases. But, levels elevated in peripheral disorders, several neuropathic conditions, including amyloid neuropathy, HIV-associated diabetic leprosy according various investigations. Theoretically, all abnormalities induced by axonal will increase blood levels, testing utilized measurement tool. predictive indicator monitor treatment efficacy neuropathy